Edward B. Lee designed this clubhouse for the Americus Republican Club in a lush Georgian style. It was built in 1918, and it spans the whole (very short) block from the Boulevard of the Allies to Third Avenue. Since the club moved out, this has been known as the Pitt Building.
Old Pa Pitt thinks the off-center pediment is an interesting choice for neo-Georgian architecture. It would not have occurred to him if he had been the architect, but the expected symmetry would probably have made a duller façade.
Update: A correspondent points out that Second Avenue was widened into a boulevard in 1921, and it was done by trimming, moving, or demolishing buildings on the north side of the street. One large building was moved back forty feet. Forty feet would be just enough to account for the asymmetry of this façade. E. B. Lee would have been available to supervise the alterations, but the building’s current form would represent the best he could do under adverse circumstances, not his original grand vision for the Americus Club.