This Renaissance house in Shadyside is now a residence for first-year students at Carnegie Mellon. The round dormer is unusual, but there was a brief fad for them around the turn of the twentieth century: see also the J. J. Matthews House.
Addendum: The architect was Frederick Osterling. This is the sole survivor of a row of three houses Osterling designed; this one was for James H. Hammond. See Works of F. J. Osterling by J. Franklin Nelson, 1904.